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Publication : Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2.

First Author  Taylor PR Year  2014
Journal  Nat Immunol Volume  15
Issue  2 Pages  143-51
PubMed ID  24362892 Mgi Jnum  J:209279
Mgi Id  MGI:5566917 Doi  10.1038/ni.2797
Citation  Taylor PR, et al. (2014) Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORgammat and dectin-2. Nat Immunol 15(2):143-51
abstractText  Here we identified a population of bone marrow neutrophils that constitutively expressed the transcription factor RORgammat and produced and responded to interleukin 17A (IL-17A (IL-17)). IL-6, IL-23 and RORgammat, but not T cells or natural killer (NK) cells, were required for IL-17 production in neutrophils. IL-6 and IL-23 induced expression of the receptors IL-17RC and dectin-2 on neutrophils, and IL-17RC expression was augmented by activation of dectin-2. Autocrine activity of IL-17A and its receptor induced the production of reactive oxygen species (ROS), and increased fungal killing in vitro and in a model of Aspergillus-induced keratitis. Human neutrophils also expressed RORgammat and induced the expression of IL-17A, IL-17RC and dectin-2 following stimulation with IL-6 and IL-23. Our findings identify a population of human and mouse neutrophils with autocrine IL-17 activity that probably contribute to the etiology of microbial and inflammatory diseases.
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