| Primary Identifier | IPR041343 | Type | Domain |
| Short Name | PRC2_HTH_1 |
| description | This domain can be found in the polycomb repressive complex 2 (PRC2) subunits EZH1 and EZH2. Three core subunits make up the catalytic core of PRC2: EZH1 or EZH2, the zinc-finger containing SUZ12 and EED. Polycomb complexes maintain repressive chromatin states by silencing gene expression. PRC2 does this by methylating lysine 27 of histone H3 []. This domain makes up part of the N-lobe which consists of EED and the N-terminal region of EZH2, and is involved in regulation []. |
