| Primary Identifier | IPR016411 | Type | Family |
| Short Name | SSB_T7 |
| description | This group represents single-stranded DNA-binding proteins (SSB, also known as helix-destabilising proteins and gp2.5) from bacteriophage T7. It is expressed in the late stage of lytic development, binding preferentially to single-stranded DNA and is implicated in DNA replication, formation of concatemers, recombination and repair of double-stranded breaks [, , , , ]. Together with DNA primase/helicase, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions and mediates homologous DNA strand exchange []. SSB disrupts loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation []. The C-terminal aromatic Phe and the overall acidic charge of this region are critical for its function []. |
