| First Author | Keir WJ | Year | 1991 |
| Journal | Genomics | Volume | 9 |
| Issue | 2 | Pages | 390-5 |
| PubMed ID | 1848528 | Mgi Jnum | J:11063 |
| Mgi Id | MGI:59505 | Doi | 10.1016/0888-7543(91)90272-g |
| Citation | Keir WJ, et al. (1991) The cDNA sequence and chromosomal location of the murine GABAA alpha 1 receptor gene. Genomics 9(2):390-5 |
| abstractText | The murine GABAA/benzodiazepine (GABAA/BZ) receptor alpha 1 subunit cDNA has been isolated from a BALB/c mouse brain library and sequenced. The cDNA is 2665 nucleotides long with an open reading frame of 455 amino acids. It shows significant homology to the GABAA receptor alpha 1 subunit cDNA sequences of other species. Excluding deletions, the murine GABAA alpha 1 receptor exhibits 96% nucleotide and 100% amino acid sequence homology to the rat alpha 1 receptor cDNA and over 91% nucleotide and 98% amino acid sequence homology to the bovine and human alpha 1 receptor cDNAs in the protein coding region. This murine cDNA was used to locate the alpha 1 receptor subunit gene, Gabra-1, to murine Chromosome 11 between Il-3 and Rel. This assignment extends proximally the segment of mouse Chromosome 11 with known homology to human chromosome 5. |
