| First Author | Shen Y | Year | 2020 |
| Journal | Cell Rep | Volume | 30 |
| Issue | 9 | Pages | 3079-3091.e5 |
| PubMed ID | 32130908 | Mgi Jnum | J:287657 |
| Mgi Id | MGI:6416763 | Doi | 10.1016/j.celrep.2020.02.032 |
| Citation | Shen Y, et al. (2020) Shared PPARalpha/gamma Target Genes Regulate Brown Adipocyte Thermogenic Function. Cell Rep 30(9):3079-3091.e5 |
| abstractText | Brown adipose tissue (BAT) generates heat to maintain body temperature and suppress obesity. Agonists for nuclear receptors PPARalpha and PPARgamma both affect brown adipocyte function, yet the interplay between these factors in BAT is uncertain. Here, we report that PPARalpha shares most genomic binding sites with PPARgamma, and these common binding sites are more related to BAT function than PPARgamma-selective sites without PPARalpha. Integrating PPARalpha and PPARgamma genomic occupancy with cold-responsive BAT transcriptomes identifies a subset of 16 genes with potential relevance to BAT function. Among these, we focused on the lysosomal protease cathepsin Z (CTSZ) and showed it is necessary for mitochondrial respiration in both mouse and human brown adipocytes. Thus, CTSZ is a shared PPARalpha/gamma target gene in BAT and a regulator of brown adipocyte thermogenic function. |
