| Primary Identifier | MGI:2181762 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Nfatc1 |
| Transmission | Germline | Strain of Origin | 129S2/SvPas |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Sequence encoding 19 amino acids (635-653) of the Rel-homology domain were replaced by a neomycin selection cassette. A frameshift mutation was introduced into the downstream sequence encoding amino acids 654 through 710. Western blot analysis showed the presence of truncated peptide in homozygous mutant mice. Electromobility shift assays showed a lack of DNA-binding activity. |
