| First Author | Vanneste D | Year | 2023 |
| Journal | Nat Immunol | Volume | 24 |
| Issue | 5 | Pages | 827-840 |
| PubMed ID | 36928411 | Mgi Jnum | J:338559 |
| Mgi Id | MGI:7495981 | Doi | 10.1038/s41590-023-01468-3 |
| Citation | Vanneste D, et al. (2023) MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation. Nat Immunol 24(5):827-840 |
| abstractText | Resident tissue macrophages (RTMs) are differentiated immune cells that populate distinct niches and exert important tissue-supportive functions. RTM maintenance is thought to rely either on differentiation from monocytes or on RTM self-renewal. Here, we used a mouse model of inducible lung interstitial macrophage (IM) niche depletion and refilling to investigate the development of IMs in vivo. Using time-course single-cell RNA-sequencing analyses, bone marrow chimeras and gene targeting, we found that engrafted Ly6C(+) classical monocytes proliferated locally in a Csf1 receptor-dependent manner before differentiating into IMs. The transition from monocyte proliferation toward IM subset specification was controlled by the transcription factor MafB, while c-Maf specifically regulated the identity of the CD206(+) IM subset. Our data provide evidence that, in the mononuclear phagocyte system, the ability to proliferate is not merely restricted to myeloid progenitor cells and mature RTMs but is also a tightly regulated capability of monocytes developing into RTMs in vivo. |
