Primary Identifier | MGI:1919356 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 72106 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction; positive regulation of sprouting angiogenesis; and regulation of glycolytic process. Predicted to be located in endoplasmic reticulum lumen and nucleus. Predicted to be active in cytoplasm. Is expressed in brain; gonad; lung; metanephros; and submandibular gland. Orthologous to human JMJD8 (jumonji domain containing 8). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced capillaries in muscle tissue and reduced glycolysis in isolated cells. Mice for another null allele exhibit increased insulin sensitivity and glucose tolerance. [provided by MGI curators] |