| Type | MGI:General | Description | mice exposed to chronic ultraviolet radiation show an increase in the number and size of basaloid cell tumors such that by 11 months of UV exposure, 86% of mice develop cutaneous tumors about 20% of UV-induced tumors are basal cell carcinoma or trichoblastomas, 30% are squamous cell carcinomas or keratoacanthomas, and 50% are fibrosarcomas or fibromas after 12 months of chronic UV exposure, all mice have tumors with features of basal cell carcinoma, with 44% classified as superficial, mostly interfollicular basaloid proliferations, 13% with features of nodular or infiltrating basal cell carcinoma, and 43% with features of trichoblastoma basal cell carcinoma and trichoblastoma show Ptch1 loss of heterozygosity 57% of mice receiving 11-12 months of UV exposure show invasive squamous cell carcinomas or keratoacanthomas compared to 25% of wild-type mice |
