| First Author | Calnan BJ | Year | 1995 |
| Journal | Immunity | Volume | 3 |
| Issue | 3 | Pages | 273-82 |
| PubMed ID | 7552993 | Mgi Jnum | J:28969 |
| Mgi Id | MGI:76506 | Doi | 10.1016/1074-7613(95)90113-2 |
| Citation | Calnan BJ, et al. (1995) A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity 3(3):273-82 |
| abstractText | The transcription factor Nur77, an orphan member of the nuclear hormone receptor superfamily, is highly expressed during T cell receptor-signaled apoptosis, suggesting a possible role for Nur77 in negative selection. We examined this by generating two sets of transgenic mice. In one set of mice, a dominant-negative Nur77 mutant is constitutively expressed and the other in which wild-type Nur77 protein is constitutively expressed in developing thymocytes. We report that inhibition of endogenous Nur77 by the dominant-negative mutant perturbed T cell development and inhibited antigen-induced negative selection in F5T cell receptor transgenic mice. Constitutive expression of wild-type Nur77 protein induced apoptosis in developing thymocytes, resulting in a decreased number of thymocytes and mature T cells. Together, these data support a role for Nur77 in the downstream signaling events in antigen-induced negative selection. |
