| First Author | Seltzer Z | Year | 2001 |
| Journal | Pain | Volume | 93 |
| Issue | 2 | Pages | 101-6 |
| PubMed ID | 11427320 | Mgi Jnum | J:70963 |
| Mgi Id | MGI:2148735 | Doi | 10.1016/S0304-3959(01)00295-0 |
| Citation | Seltzer Z, et al. (2001) Mapping a gene for neuropathic pain-related behavior following peripheral neurectomy in the mouse. Pain 93(2):101-6 |
| abstractText | Total hindpaw denervation in rodents elicits an abnormal behavior of licking, scratching and self-injury of the anesthetic limb ('autotomy'). Since the same denervation produces phantom limb pain and anesthesia dolorosa in humans, autotomy has been used as a model of human neuropathic pain. Autotomy is an inherited trait in rodents, attributable to a few genes of major effect. Here we used recombinant inbred (RI) mouse lines of the AXB-BXA RI set to map a gene for autotomy. Autotomy levels following unilateral sciatic and saphenous nerve section were scored daily for 36 days, using a standardized scale, in all 23 RI lines available for this set. We used a genetic map of 395 marker loci and a permutation-based statistical method for categorical data to assess the statistical significance of mapping results. We identified a marker on chromosome 15 with statistical support (P=0.0003) in the range considered significant for genome-wide scans in the mouse. Several genes located in this chromosomal region encode for neural functions related to neuropathic pain and may indicate targets for development of novel analgesics. |
