| First Author | Ko J | Year | 2004 |
| Journal | Oncogene | Volume | 23 |
| Issue | 10 | Pages | 1950-3 |
| PubMed ID | 14691448 | Mgi Jnum | J:87538 |
| Mgi Id | MGI:3027077 | Doi | 10.1038/sj.onc.1207356 |
| Citation | Ko J, et al. (2004) Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice. Oncogene 23(10):1950-3 |
| abstractText | Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor. |
