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Protein Coding Gene : Trim72 tripartite motif-containing 72

Primary Identifier  MGI:3612190 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  434246
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables phosphatidylserine binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Involved in several processes, including muscle organ development; plasma membrane repair; and protein homooligomerization. Acts upstream of or within negative regulation of myotube differentiation; negative regulation of signal transduction; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasmic vesicle membrane and sarcolemma. Is expressed in heart and skeletal muscle. Orthologous to human TRIM72 (tripartite motif containing 72).
PHENOTYPE: Mice with disruption of this gene display muscle pathologies that develop with age. Mice homozygous for a knock-out allele exhibit enhanced myogenesis. Homozygosity for the p.C14A mutation ameliorates the effects of a high-fat diet without affecting susceptibility to myocardial ischemic injury. [provided by MGI curators]
  • synonyms:
  • tripartite motif-containing 72,
  • Trim72,
  • mitsugumin 53,
  • MG53,
  • cDNA sequence BC067209,
  • BC067209

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Genome

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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