| First Author | Yang T | Year | 2018 |
| Journal | Neuroscience | Volume | 380 |
| Pages | 90-102 | PubMed ID | 29660444 |
| Mgi Jnum | J:262718 | Mgi Id | MGI:6162137 |
| Doi | 10.1016/j.neuroscience.2018.04.004 | Citation | Yang T, et al. (2018) Ca(2+)-Binding Protein 1 Regulates Hippocampal-dependent Memory and Synaptic Plasticity. Neuroscience 380:90-102 |
| abstractText | Ca(2+)-binding protein 1 (CaBP1) is a Ca(2+)-sensing protein similar to calmodulin that potently regulates voltage-gated Ca(2+) channels. Unlike calmodulin, however, CaBP1 is mainly expressed in neuronal cell-types and enriched in the hippocampus, where its function is unknown. Here, we investigated the role of CaBP1 in hippocampal-dependent behaviors using mice lacking expression of CaBP1 (C-KO). By western blot, the largest CaBP1 splice variant, caldendrin, was detected in hippocampal lysates from wild-type (WT) but not C-KO mice. Compared to WT mice, C-KO mice exhibited mild deficits in spatial learning and memory in both the Barnes maze and in Morris water maze reversal learning. In contextual but not cued fear-conditioning assays, C-KO mice showed greater freezing responses than WT mice. In addition, the number of adult-born neurons in the hippocampus of C-KO mice was approximately 40% of that in WT mice, as measured by bromodeoxyuridine labeling. Moreover, hippocampal long-term potentiation was significantly reduced in C-KO mice. We conclude that CaBP1 is required for cellular mechanisms underlying optimal encoding of hippocampal-dependent spatial and fear-related memories. |
