| Primary Identifier | IPR033037 | Type | Family |
| Short Name | Ackr2 |
| description | Atypical chemokine receptor 2 (ACKR2/D6) [], previously known as CCR9 or CCR10 [], is a chemokine-scavenging receptor or chemokine decoy receptor. It is capable of internalising and effectively scavenging its ligands through beta-arrestin-dependent activation of the cofilin pathway [, ]. ACKR2 is highly promiscuous and can bind the majority of (if not all) inflammatory CC-chemokines []. It plays an essential role in the resolution of the inflammatory response [, , ]. Although it lacks the canonical DRYLAIV motif necessary for classical signalling, ACKR2/D6 may be involved in 'atypical' signalling pathways downstream of ligand binding []. It has been shown to be involved in regulating vessel density []. |
