Primary Identifier | IPR031293 | Type | Family |
Short Name | Anoctamin-4 |
description | The anoctamin/TMEM16 family members include Ano1-10 (TMEM16A-J). They are membrane proteins involved in a variety of physiological functions, such as ion transport and ion channel regulation. TMEM16A and 16B are Ca(2+)-dependent Cl(-) channels; TMEM16C, 16D, 16F, 16G, and 16J have been classified as Ca(2+)-dependent lipid scramblases []. The anoctamin/TMEM16 family might have diverged in two or three different subclasses, channels, scramblases and dual-function channel/scramblases [].Scramblases catalyse bidirectional transbilayer movement of the major classes of phospholipids. Anoctamin-4 (Ano4, TMEM16D) has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide []. |