| Primary Identifier | MGI:1915826 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 68576 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Predicted to be involved in several processes, including positive regulation of interleukin-8 production; positive regulation of intracellular signal transduction; and positive regulation of protein localization to nucleus. Predicted to be located in cytosol. Predicted to be part of FNIP-folliculin RagC/D GAP and Ragulator complex. Predicted to be active in lysosomal membrane. Is expressed in embryo. Orthologous to human LAMTOR5 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 5). PHENOTYPE: Pancreatic beta-cell specific knockout mice exhibit higher fasting blood gluose levels, impaired glucose tolerance and decreased insulin secretion from islets. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
