| First Author | Chan OT | Year | 2000 |
| Journal | J Immunol | Volume | 164 |
| Issue | 4 | Pages | 1658-62 |
| PubMed ID | 10657607 | Mgi Jnum | J:60396 |
| Mgi Id | MGI:1353242 | Doi | 10.4049/jimmunol.164.4.1658 |
| Citation | Chan OT, et al. (2000) Cutting edge: B cells promote CD8+ T cell activation in MRL-Fas(lpr) mice independently of MHC class I antigen presentation. J Immunol 164(4):1658-62 |
| abstractText | Spontaneous CD8+ T cell activation in MRL-Faslpr mice is B cell dependent. It is unclear whether this B-dependent activation is mediated by direct Ag presentation via MHC class I proteins (i.e., cross-presentation) or whether activation occurs by an indirect mechanism, e.g., via effects on CD4+ cells. To determine how CD8+ T cell activation is promoted by B cells, we created mixed bone marrow chimeras where direct MHC class I Ag presentation by B cells was abrogated while other leukocyte compartments could express MHC class I. Surprisingly, despite the absence of B cell class I-restricted Ag presentation, CD8+ T cell activation was intact in the chimeric mice. Therefore, the spontaneous B cell-dependent CD8+ T cell activation that occurs in systemic autoimmunity is not due to direct presentation by B cells to CD8+ T cells. |
