| First Author | Wüthrich M | Year | 2005 |
| Journal | Infect Immun | Volume | 73 |
| Issue | 11 | Pages | 7436-41 |
| PubMed ID | 16239544 | Mgi Jnum | J:104194 |
| Mgi Id | MGI:3611502 | Doi | 10.1128/IAI.73.11.7436-7441.2005 |
| Citation | Wuthrich M, et al. (2005) CD28 is required for optimal induction, but not maintenance, of vaccine-induced immunity to Blastomyces dermatitidis. Infect Immun 73(11):7436-41 |
| abstractText | Cellular immunity mediated by T lymphocytes, in particular CD4+ and CD8+ type 1 cells, is the main defense against pathogenic fungi. Here, CD28-deficient (CD28-/-) mice were used to study the role of costimulation for the generation and maintenance of T-cell-mediated, type 1 cytokine-dependent mechanisms of vaccine immunity to Blastomyces dermatitidis infection. Disruption of CD28 costimulation reduced the number of type 1 CD4 and CD8 cells generated and impaired resistance to infection. Type 1 T-cell subsets generated in vaccinated CD28-/- mice were durable and protected mice for at least 3 months after vaccination. Our findings suggest that CD28 is required for the induction of optimal, protective T-cell responses to B. dermatitidis infection but may be dispensable for the maintenance of T-cell memory. |
