| First Author | Fang J | Year | 1997 |
| Journal | Biochem Biophys Res Commun | Volume | 231 |
| Issue | 3 | Pages | 655-61 |
| PubMed ID | 9070865 | Mgi Jnum | J:38627 |
| Mgi Id | MGI:86013 | Doi | 10.1006/bbrc.1997.6162 |
| Citation | Fang J, et al. (1997) Genes coding for mouse activin beta C and beta E are closely linked and exhibit a liver-specific expression pattern in adult tissues. Biochem Biophys Res Commun 231(3):655-61 |
| abstractText | Five activin beta subunits have been isolated to date, and a comparative analysis of amino acid identity has suggested that the activin beta(C), beta(D) and beta(E) subunits represent a distinct subset. Based on genomic cloning studies, we now report that the mouse activin beta(C) and beta(E) genetic loci are closely linked-i.e, the coding sequences are separated by 5.5-kbp. These genes also show similarities in structural organization as well as a unique liver-restricted pattern of expression in adult mice. Our results suggest that tandem duplication of an ancestral gene generated the mouse activin beta(C) and beta(E) genetic loci, and they provide further evidence for the postulate that the beta(C)-beta(E) subunits form a distinct subset of related activins. To our knowledge, this report is the first to demonstrate close chromosomal linkage between members of the TGF-beta superfamily as well as a liver-restricted expression pattern for a TGF- beta-like gene. (C) 1997 Academic Press. |
