| Type | MGI:General | Description | at 8-12 weeks of age, homozygotes display a marked loss of adenylyl cyclase activity in a striatum-specific manner with a small increase in the expression of other adenylyl cyclase isoforms D1 dopaminergic agonist-stimulated adenylyl cyclase activity is attenuated, along with a reduction in the expression of the D1 dopaminergic receptor and Gsalpha D2 dopaminergic agonist-mediated inhibition of adenylyl cyclase activity is blunted |
