| Primary Identifier | MGI:96434 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 16002 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables protein kinase activator activity and signaling receptor binding activity. Involved in several processes, including embryonic placenta development; positive regulation of developmental growth; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of or within several processes, including exocrine pancreas development; positive regulation of transcription by RNA polymerase II; and striated muscle cell differentiation. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; extraembryonic component; and sensory organ. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2). PHENOTYPE: Mutations that are paternally transmitted result in growth deficiency. Heterozygous mice inheriting a mutant allele from their mother appear to be phenotypically normal. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
