| First Author | Jack RS | Year | 1977 |
| Journal | Eur J Immunol | Volume | 7 |
| Issue | 8 | Pages | 559-65 |
| PubMed ID | 409605 | Mgi Jnum | J:20308 |
| Mgi Id | MGI:68407 | Doi | 10.1002/eji.1830070813 |
| Citation | Jack RS, et al. (1977) Idiotypic analysis of the response of C57BL/6 mice to the (4-hydroxy-3-nitrophenyl)acetyl group. Eur J Immunol 7(8):559-65 |
| abstractText | Strain C57BL/6 mice produce a highly restricted primary response to the (4-hydroxy-3-nitrophenyl)acetyl (NP) group. This response is composed of molecules having mu or gamma1 heavy chains and light chains of the lambda type. A guinea pig anti-idiotype was raised to the purified C57BL/6 primary anti-NP immunoglobulin. After suitable absorption, this anti-idiotype was shown to detect markers present on the primary anti-NP immunoglobulin only of those strains which express the Ig-1b allotype. Breeding experiments demonstrated that the marker segregated with the heavy chain linkage group. |
