| Primary Identifier | MGI:106299 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 52864 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable enzyme activator activity. Involved in positive regulation of t-circle formation and t-circle formation. Predicted to be located in several cellular components, including chromosome, telomeric region; cytosol; and nucleoplasm. Predicted to be part of ERCC4-ERCC1 complex; Holliday junction resolvase complex; and chromosome. Used to study Fanconi-like syndrome. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group P. Orthologous to human SLX4 (SLX4 structure-specific endonuclease subunit). PHENOTYPE: Mice homozygous for a knock-out allele exhibit some preweaning lethality, reduced fertility, abnormal eye morphology, abnormal skeletal morphology, hydrocephalus, chromosomal instability, early cellular replicative senescence, and abnormal lymphopoeisis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
