| First Author | Rajagopal K | Year | 1999 |
| Journal | J Exp Med | Volume | 190 |
| Issue | 11 | Pages | 1657-68 |
| PubMed ID | 10587356 | Mgi Jnum | J:64938 |
| Mgi Id | MGI:1891483 | Doi | 10.1084/jem.190.11.1657 |
| Citation | Rajagopal K, et al. (1999) RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation. J Exp Med 190(11):1657-68 |
| abstractText | A novel T cell-specific adaptor protein, RIBP, was identified based on its ability to bind Rlk/Txk in a yeast two-hybrid screen of a mouse T cell lymphoma library. RIBP was also found to interact with a related member of the Tec family of tyrosine kinases, Itk. Expression of RIBP is restricted to T and natural killer cells and is upregulated substantially after T cell activation. RIBP-disrupted knockout mice displayed apparently normal T cell development. However, proliferation of RIBP-deficient T cells in response to T cell receptor (TCR)-mediated activation was significantly impaired. Furthermore, these activated T cells were defective in the production of interleukin (IL)-2 and interferon gamma, but not IL-4. These data suggest that RIBP plays an important role in TCR-mediated signal transduction pathways and that its binding to Itk and Rlk/Txk may regulate T cell differentiation. |
