| Primary Identifier | MGI:1934835 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 93765 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables ubiquitin conjugating enzyme activity. Involved in protein K63-linked ubiquitination. Acts upstream of or within ubiquitin-dependent protein catabolic process. Located in nucleus. Is expressed in brain. Orthologous to human UBE2N (ubiquitin conjugating enzyme E2 N). PHENOTYPE: Homozygous disruption of this gene causes early embryonic lethality. Mice heterozygous for a gene trap allele show increased resistance to LPS-induced lethality while cultured immune cells display blunted LPS-inducible cytokine secretion and impaired activation of TRAF-mediated signal transduction. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
