Primary Identifier | MGI:5634782 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Cetn2 |
Transmission | Germline | Strain of Origin | 129 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Mice carrying the Cetn2tm1Wbae allele were crossed with an EIIa-Cre driver to eliminate the neo cassette and delete exons 2 and 3. Truncated mRNA (encompassing exons 1, 4, and 5) was detectable by RT/PCR but at very low levels (5-10% of wild-type). The truncated protein was undetectable in mutant olfactory epithelia by immunostaining, indicating that this is a null allele. |