| Primary Identifier | MGI:7516143 | Allele Type | Endonuclease-mediated |
| Gene | Sting1 | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Serine codon 365 (AGT) in exon 8 was changed to alanine (GCT) (p.S365A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation changes a phosphorylatable residue in the encoded peptide into a phosphoblocker, which selectively inactivates the IFN signaling activity of the protein. |
