| First Author | Abe TK | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 372 |
| Issue | 3 | Pages | 418-22 |
| PubMed ID | 18477476 | Mgi Jnum | J:137544 |
| Mgi Id | MGI:3801217 | Doi | 10.1016/j.bbrc.2008.05.008 |
| Citation | Abe TK, et al. (2008) Dynactin is essential for growth cone advance. Biochem Biophys Res Commun 372(3):418-22 |
| abstractText | Dynactin is a multi-subunit complex that serves as a critical cofactor of the microtubule motor cytoplasmic dynein. We previously identified dynactin in the nerve growth cone. However, the function of dynactin in the growth cone is still unclear. Here we show that dynactin in the growth cone is required for constant forward movement of the growth cone. Chromophore-assisted laser inactivation (CALI) of dynamitin, a dynactin subunit, within the growth cone markedly decreases the rate of growth cone advance. CALI of dynamitin in vitro dissociates another dynactin subunit, p150(Glued), from dynamitin. These results indicate that dynactin, especially the interaction between dynamitin and p150(Glued), plays an essential role in growth cone advance. |
