| Primary Identifier | MGI:109559 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 19279 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables protein kinase binding activity and protein tyrosine phosphatase activity. Predicted to be involved in ERBB2 signaling pathway; negative regulation of ERK1 and ERK2 cascade; and negative regulation of epithelial cell migration. Predicted to be located in cytoplasm and membrane. Predicted to be active in cell junction; cytosol; and plasma membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; and retina nuclear layer. Orthologous to human PTPRR (protein tyrosine phosphatase receptor type R). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased ERK1/2 phosphorylation levels in cerebellar Purkinje cells, decreased grip strength, and ataxia characterized by fine motor coordination and balance defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
