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Protein Coding Gene : Akap12 A kinase anchor protein 12
Primary Identifier  MGI:1932576 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  83397
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable adenylate cyclase binding activity. Involved in modulation of chemical synaptic transmission. Is active in Schaffer collateral - CA1 synapse. Is expressed in central nervous system; gut; neural ectoderm; renal interstitium; and retina. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12).
PHENOTYPE: Mice homozygous for a knockout allele disrupting all three common isoforms suffer from prostatic hyperplasia and focal dysplasia, and from delayed fertility. Mice homozygous for a gene trap allele exhibit enhanced cardiac function. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-26034,
  • SSeCKS,
  • v-src suppressed transcript 5,
  • testis specific gene A12,
  • MGI:1194895,
  • Akap12,
  • Tsga12,
  • MGI:104598,
  • MGI:2143574,
  • Srcs5,
  • expressed sequence AI317366,
  • AI317366,
  • A kinase anchor protein 12
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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

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6 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

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Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

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