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Comment :

Type  MGI:General Description  ex vivo, dissected E13.5 palate shelves placed in proximal apposition do fuse after 2 days in culture but the gap between the two shelves is not fully filled by mesenchymal cells and a fraction of midline epithelial seam is still present while expression of epithelial cytokeratins is not completely eliminated in the medial edge epithelium (MEE), unlike in control palate shelves