| First Author | García-Gutiérrez P | Year | 2011 |
| Journal | EMBO Rep | Volume | 12 |
| Issue | 10 | Pages | 1018-23 |
| PubMed ID | 21836637 | Mgi Jnum | J:200491 |
| Mgi Id | MGI:5508720 | Doi | 10.1038/embor.2011.152 |
| Citation | Garcia-Gutierrez P, et al. (2011) The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators. EMBO Rep 12(10):1018-23 |
| abstractText | Covalent attachment of small ubiquitin-like modifier (SUMO) to proteins regulates many processes in the eukaryotic cell. This reaction is similar to ubiquitination and usually requires an E3 ligase for substrate modification. However, only a few SUMO ligases have been described so far, which frequently facilitate sumoylation by bringing together the SUMO-conjugating enzyme Ubc9 and the target protein. Ubc9 is an interaction partner of the transcription factor Krox20, a key regulator of hindbrain development. Here, we show that Krox20 functions as a SUMO ligase for its coregulators--the Nab proteins--and that Nab sumoylation negatively modulates Krox20 transcriptional activity in vivo. |
