| First Author | Bertin S | Year | 2014 |
| Journal | Nat Immunol | Volume | 15 |
| Issue | 11 | Pages | 1055-1063 |
| PubMed ID | 25282159 | Mgi Jnum | J:241630 |
| Mgi Id | MGI:5903206 | Doi | 10.1038/ni.3009 |
| Citation | Bertin S, et al. (2014) The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4(+) T cells. Nat Immunol 15(11):1055-63 |
| abstractText | TRPV1 is a Ca(2+)-permeable channel studied mostly as a pain receptor in sensory neurons. However, its role in other cell types is poorly understood. Here we found that TRPV1 was functionally expressed in CD4(+) T cells, where it acted as a non-store-operated Ca(2+) channel and contributed to T cell antigen receptor (TCR)-induced Ca(2+) influx, TCR signaling and T cell activation. In models of T cell-mediated colitis, TRPV1 promoted colitogenic T cell responses and intestinal inflammation. Furthermore, genetic and pharmacological inhibition of TRPV1 in human CD4(+) T cells recapitulated the phenotype of mouse Trpv1(-/-) CD4(+) T cells. Our findings suggest that inhibition of TRPV1 could represent a new therapeutic strategy for restraining proinflammatory T cell responses. |
