Primary Identifier | MGI:5141514 | Allele Type | Targeted |
Gene | Cdk6 | Transmission | Germline |
Strain of Origin | Not Specified | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Exon 1 was replaced with one in which nucleotide substitutions result in the amino acid substitution of cystine for arginine at position 31 (R31C). A floxed stop cassette downstream of the modified exon 1 that prevents expression was removed by cre-mediated recombination. The product is predicted to be a hyperactivate kinase. |