|  Help  |  About  |  Contact Us

Protein Coding Gene : Usp14 ubiquitin specific peptidase 14

Primary Identifier  MGI:1928898 Organism  mouse, laboratory
Chromosome  18 NCBI Gene Number  59025
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Acts upstream of or within chemical synaptic transmission. Located in synapse. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human USP14 (ubiquitin specific peptidase 14).
PHENOTYPE: Homozygotes for a hypomorphic mutation develop severe tremors by 3 weeks of age, followed by hindlimb paralysis and premature death. An underdeveloped corpus callosum, hippocampus, dentate gyrus and forebrain structures, and notable defects in synaptic transmission in both the CNS and PNS are seen. [provided by MGI curators]
  • synonyms:
  • ax,
  • expressed sequence C78769,
  • expressed sequence AW107924,
  • neuroscience mutagenesis facility, 375,
  • MGI:2147346,
  • dUB-type TGT,
  • nmf375,
  • NMF375,
  • MGI:2147405,
  • MGD-MRK-1488,
  • AW107924,
  • 2610005K12Rik,
  • 2610037B11Rik,
  • RIKEN cDNA 2610005K12 gene,
  • Usp14,
  • ataxia,
  • MGI:1919366,
  • MGI:3622125,
  • C78769,
  • MGI:1919708,
  • ubiquitin specific peptidase 14,
  • MGI:88124,
  • RIKEN cDNA 2610037B11 gene

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

2 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

28 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For