| First Author | Duan W | Year | 2000 |
| Journal | Gene | Volume | 256 |
| Issue | 1-2 | Pages | 113-21 |
| PubMed ID | 11054541 | Mgi Jnum | J:65465 |
| Mgi Id | MGI:1926628 | Doi | 10.1016/s0378-1119(00)00365-6 |
| Citation | Duan W, et al. (2000) Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo. Gene 256(1-2):113-21 |
| abstractText | We describe the cloning and expression of cDNAs encoding a novel human protein of 208 amino acid residues with a predicted molecular mass of 22.6kDa and its mouse homologue. We name this protein as AWP1 (associated with PRK1). AWP1 is a ubiquitously expressed protein, and the Awp1 gene is switched on during early human and mouse development. When expressed in COS-1 cells, the Myc-tagged AWP1 has an apparent molecular mass higher than that deduced from its amino acid sequence. AWP1 possesses a conserved zf-A20 zinc finger domain at its N-terminal and a zf-AN1 zinc finger domain at its C-terminal. Co-immunoprecipitation experiments revealed that mouse AWP1 specifically interacts with a rat serine/threonine protein kinase PRK1 in vivo. Hence, AWP1 may play a regulatory role in mammalian signal transduction pathways. |
