| First Author | Valdar W | Year | 2006 |
| Journal | Nat Genet | Volume | 38 |
| Issue | 8 | Pages | 879-87 |
| PubMed ID | 16832355 | Mgi Jnum | J:111630 |
| Mgi Id | MGI:3654596 | Doi | 10.1038/ng1840 |
| Citation | Valdar W, et al. (2006) Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat Genet 38(8):879-87 |
| abstractText | Difficulties in fine-mapping quantitative trait loci (QTLs) are a major impediment to progress in the molecular dissection of complex traits in mice. Here we show that genome-wide high-resolution mapping of multiple phenotypes can be achieved using a stock of genetically heterogeneous mice. We developed a conservative and robust bootstrap analysis to map 843 QTLs with an average 95% confidence interval of 2.8 Mb. The QTLs contribute to variation in 97 traits, including models of human disease (asthma, type 2 diabetes mellitus, obesity and anxiety) as well as immunological, biochemical and hematological phenotypes. The genetic architecture of almost all phenotypes was complex, with many loci each contributing a small proportion to the total variance. Our data set, freely available at http://gscan.well.ox.ac.uk, provides an entry point to the functional characterization of genes involved in many complex traits. |
