| First Author | Ware CB | Year | 2005 |
| Journal | FEBS Lett | Volume | 579 |
| Issue | 20 | Pages | 4465-9 |
| PubMed ID | 16081071 | Mgi Jnum | J:100335 |
| Mgi Id | MGI:3588007 | Doi | 10.1016/j.febslet.2005.07.014 |
| Citation | Ware CB, et al. (2005) Leukemia inhibitory factor signaling is implicated in embrionic development of the HPA axis. FEBS Lett 579(20):4465-9 |
| abstractText | Leukemia inhibitory factor (LIF) is expressed in the hypothalamic-pituitary adrenal (HPA) axis and stimulates pituitary POMC transcription. The role of LIF receptor signaling in HPA axis development was examined. Lifr -/- and Lifr +/+ fetuses were obtained by Cesarean section on E18.5. Despite a 3-fold induction of hypothalamic CRH mRNA, pituitary POMC mRNA and RU486-induced ACTH levels were decreased in Lifr -/- mice. High CRH may be caused by increased central TNFalpha and IL-6 expression. Lifr -/- mice demonstrate elevated pituitary glucocorticoid (GR) and mineralocorticoid (MR) receptor mRNA and protein levels, indicating the importance of LIF signaling for HPA axis development. |
