| Primary Identifier | IPR033024 | Type | Family |
| Short Name | Neogenin |
| description | Neogenin (NEO1) is a multifunctional transmembrane receptor belonging to the immunoglobulin superfamily []. It displays identical secondary structure to DCC (deleted in colorectal cancer), a netrin receptor that is involved in axon guidance and cell survival. Similar to DCC, it is able to transduce signals elicited by netrin []. Netrin-Neogenin interactions result in a chemoattractive axon guidance response []. Neogenin is also a receptor for members of the repulsive guidance molecule (RGM) family, which act as a repulsive axon guidance cue [, , ]. RGM binding to NEO1 activates the bone morphogenetic protein (BMP)-regulated signalling involved in morphogenesis and iron homeostasis [, ].Neogenin has an important role in cancer development [, ]. |
