| Primary Identifier | MGI:96756 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 16818 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including CD4 receptor binding activity; protein antigen binding activity; and protein phosphatase binding activity. Involved in release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including B cell receptor signaling pathway; positive regulation of macromolecule metabolic process; and regulation of T cell differentiation. Located in cell-cell junction. Colocalizes with plasma membrane. Is expressed in several structures, including 2-cell stage embryo; nervous system; neural ectoderm; sensory organ; and thymus primordium. Human ortholog(s) of this gene implicated in immunodeficiency 22. Orthologous to human LCK (LCK proto-oncogene, Src family tyrosine kinase). PHENOTYPE: Mice homozygous for mutations of this gene exhibit thymic atrophy with reduced numbers of peripheral T cells. Null mutants have few double positive and no mature single positive (SP) thymocytes. A hypomorph has decreased expression of CD3epsilon chain on SP thymocytes, whose numbers are reduced. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
