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Protein Coding Gene : Ndst3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
Primary Identifier  MGI:1932544 Organism  mouse, laboratory
Chromosome  3 NCBI Gene Number  83398
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables N-acetylglucosamine deacetylase activity and [heparan sulfate]-glucosamine N-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including future brain; genitourinary system; heart; nervous system; and retina. Orthologous to human NDST3 (N-deacetylase and N-sulfotransferase 3).
PHENOTYPE: Mice homozygous for a knockout allele exhibit decreased anxiety-related behavior, cholesterol levels and CD8+ T cells due to moderate heparan-sulfate undersulfation. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 4921531K01 gene,
  • 4921531K01Rik,
  • N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3,
  • 4930511P15Rik,
  • MGI:1921948,
  • RIKEN cDNA 4930511P15 gene,
  • MGI:1918208,
  • Ndst3
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