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Protein Coding Gene : Cnn2 calponin 2

Primary Identifier  MGI:105093 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  12798
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable actin filament binding activity. Acts upstream of or within several processes, including negative regulation of macrophage migration; negative regulation of phagocytosis; and regulation of mononuclear cell proliferation. Predicted to be located in stress fiber. Predicted to be active in actin cytoskeleton. Is expressed in several structures, including allantois; central nervous system; eye; forelimb; and lateral plate mesoderm. Orthologous to human CNN2 (calponin 2).
PHENOTYPE: Mice homozygous for either a knock-out or a knock-down allele have reduced numbers of peripheral blood neutrophils and monocytes. Knock-out mice show increased macrophage proliferation, motility and phagocytosis, faster diapedesis of peripheral monocytesand neutrophils, and enhanced wound healing. [provided by MGI curators]
  • synonyms:
  • h2-calponin,
  • Calpo2,
  • MGI:2143461,
  • MGD-MRK-32133,
  • AI324678,
  • expressed sequence AA408047,
  • calponin 2,
  • Cnn2,
  • MGI:2143578,
  • expressed sequence AI324678,
  • AA408047

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

3 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For