| First Author | Reynolds JM | Year | 2012 |
| Journal | J Immunol | Volume | 189 |
| Issue | 9 | Pages | 4226-30 |
| PubMed ID | 23024280 | Mgi Jnum | J:190603 |
| Mgi Id | MGI:5449290 | Doi | 10.4049/jimmunol.1103014 |
| Citation | Reynolds JM, et al. (2012) Cutting edge: regulation of intestinal inflammation and barrier function by IL-17C. J Immunol 189(9):4226-30 |
| abstractText | In the IL-17 family of cytokines, much is known about the sources and functions of IL-17, IL-17F, and IL-25 in the host defense against infection and in inflammatory diseases; however, the physiological function of IL-17C remains poorly understood. Using mice deficient in IL-17C, we demonstrate that this cytokine is crucial for the regulation of an acute experimental colitis elicited by dextran sulfate sodium. In this model, mice lacking IL-17C exhibited exacerbated disease that was associated with increased IL-17 expression by gammadelta T cells and Th17 cells. Moreover, IL-17C directly regulated the expression of the tight junction molecule occludin by colonic epithelial cells. Thus, our data suggest that IL-17C plays a critical role in maintaining mucosal barrier integrity. |
