| First Author | Poirier C | Year | 2007 |
| Journal | Genesis | Volume | 45 |
| Issue | 7 | Pages | 452-5 |
| PubMed ID | 17607692 | Mgi Jnum | J:125027 |
| Mgi Id | MGI:3723377 | Doi | 10.1002/dvg.20312 |
| Citation | Poirier C, et al. (2007) Three loci on mouse chromosome 5 and 10 modulate sex determination in XX Ods/+ mice. Genesis 45(7):452-5 |
| abstractText | In mouse, XY embryos are committed to the male sex determination pathway after the transient expression of the Y-linked Sry gene in the Sertoli cell lineage between 10.5 and 12.5 dpc. In the C57BL/6J strain, male sex determination program can be modulated by some autosomal genes. The C57BL/6J alleles at these autosomal loci can antagonize male sex determination in combination with specific Sry alleles. In this report, the authors have identified an effect of these C57BL/6J specific alleles in combination with a mutated Sox9 allele, Sox9(Ods). Authors report the mapping of three of these genetic loci on mouse chromosome 5 and 10 in a backcross of the Ods mutation to the C57BL/6J background. Our study confirms the importance of the strain C57BL/6J for the investigation of the genetic mechanisms that control sex determination. |
