| First Author | Ueno M | Year | 2001 |
| Journal | Biochem Biophys Res Commun | Volume | 287 |
| Issue | 2 | Pages | 501-6 |
| PubMed ID | 11554756 | Mgi Jnum | J:344694 |
| Mgi Id | MGI:7579252 | Doi | 10.1006/bbrc.2001.5587 |
| Citation | Ueno M, et al. (2001) Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion. Biochem Biophys Res Commun 287(2):501-6 |
| abstractText | Recent studies have suggested the existence of progenitors common to hematopoietic and endothelial cells, called hemangioblasts, in, for instance, embryonic dorsal aorta. To identify a membrane-bound or secretory molecule regulating early hematopoiesis, we screened a cDNA library from dorsal aortas of embryonic day (E) 10.5 mice by a signal sequence trap method and obtained a clone encoding a sialoprotein, endomucin-1. Immunohistochemistry revealed that the endomucin-1 transcript was specifically expressed in the endothelial cells of dorsal aorta of E10.5 mouse embryo. Overexpression of endomucin-1 strongly inhibited adhesion and aggregation of cells, including cultured endothelial cells from E10.5 dorsal aorta. These data suggest that endomucin-1 may play a role in detachment of hematopoietic cells from endothelium during early hematopoiesis. |
