| First Author | Leitges M | Year | 1996 |
| Journal | Science | Volume | 273 |
| Issue | 5276 | Pages | 788-91 |
| PubMed ID | 8670417 | Mgi Jnum | J:34818 |
| Mgi Id | MGI:82284 | Doi | 10.1126/science.273.5276.788 |
| Citation | Leitges M, et al. (1996) Immunodeficiency in protein kinase cbeta-deficient mice. Science 273(5276):788-91 |
| abstractText | Cross-linking of the antigen receptor on lymphocytes by antigens or antibodies to the receptor results in activation of enzymes of the protein kinase C (PKC) family. Mice homozygous for a targeted disruption of the gene encoding the PKC-betaI and PKC-betaII isoforms develop an immunodeficiency characterized by impaired humoral immune responses and reduced cellular responses of B cells, which is similar to X-linked immunodeficiency in mice. Thus PKC-betaI and PKC-betaII play an important role in B cell activation and may be functionally linked to Bruton's tyrosine kinase in antigen receptor-mediated signal transduction. |
