| First Author | Saito H | Year | 2017 |
| Journal | Nat Commun | Volume | 8 |
| Pages | 16011 | PubMed ID | 28685774 |
| Mgi Jnum | J:250590 | Mgi Id | MGI:5920153 |
| Doi | 10.1038/ncomms16011 | Citation | Saito H, et al. (2017) Immobility responses are induced by photoactivation of single glomerular species responsive to fox odour TMT. Nat Commun 8:16011 |
| abstractText | Fox odour 2,4,5-trimethyl thiazoline (TMT) is known to activate multiple glomeruli in the mouse olfactory bulb (OB) and elicits strong fear responses. In this study, we screened TMT-reactive odourant receptors and identified Olfr1019 with high ligand reactivity and selectivity, whose glomeruli are located in the posterodorsal OB. In the channelrhodopsin knock-in mice for Olfr1019, TMT-responsive olfactory-cortical regions were activated by photostimulation, leading to the induction of immobility, but not aversive behaviour. Distribution of photoactivation signals was overlapped with that of TMT-induced signals, but restricted to the narrower regions. In the knockout mice, immobility responses were reduced, but not entirely abolished likely due to the compensatory function of other TMT-responsive glomeruli. Our results demonstrate that the activation of a single glomerular species in the posterodorsal OB is sufficient to elicit immobility responses and that TMT-induced fear may be separated into at least two different components of immobility and aversion. |
