| Primary Identifier | MGI:2151075 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 94185 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Involved in several processes, including negative regulation of cytokine production; negative regulation of lymphocyte proliferation; and oligodendrocyte apoptotic process. Located in axon and plasma membrane. Is expressed in several structures, including lip; lung; metanephros; nervous system; and nose. Orthologous to human TNFRSF21 (TNF receptor superfamily member 21). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired T cell differentiation and an enhanced Th2 response. Mice homozygous for a different knock-out allele show increased CD4+ T cell proliferation and Th2 cytokine production, and enhanced B cell proliferation, survival, and humoral responses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
