| First Author | Danko I | Year | 1992 |
| Journal | Pediatr Res | Volume | 32 |
| Issue | 1 | Pages | 128-31 |
| PubMed ID | 1635838 | Mgi Jnum | J:23502 |
| Mgi Id | MGI:71573 | Doi | 10.1203/00006450-199207000-00025 |
| Citation | Danko I, et al. (1992) The frequency of revertants in mdx mouse genetic models for Duchenne muscular dystrophy. Pediatr Res 32(1):128-31 |
| abstractText | The mdx mouse has been used for the development of cellular and gene therapies for Duchenne muscular dystrophy. The relatively frequent occurrence of dystrophin-positive muscle cells called revertants has hampered these efforts by interfering with data interpretation. The mdx4cv and mdx5cv dystrophin mouse mutants have approximately 10-fold fewer revertants than the mdx mutant at both 2 and 6 mo. The mdx3cv dystrophin mouse mutant may be a useful model for some types of human dystrophin deficiencies in which the levels of dystrophin are low but not completely absent. |
